Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity. Department of pharmaceutics and research, swamy vivekanandha college of pharmacy, tiruchengode637205, tamil nadu, india. Niosomes are capable of entrapping hydrophilic and hydrophobic solutes. Niosomes of aceclofenac were formulated by an ether injection method using different concentrations of drug, cholesterol and surfactant span.
The low cost, greater stability and ease of preparation of non. Topically applied niosomes can increase the residence time of drugs in the stratum corneum and epidermis, while reducing the systemic absorption of the drug. Niosomes play an increasingly important role in drug delivery as they can reduce toxicity and modify pharmacokinetic and bioavailability. Formulation and evaluation of sustained released niosomes. Thulasi1, mariyam ahmed1, muna yousuf ali1 1bojjam narasimhulu pharmacy college for women, hyderabad, 500059. Span 80 and cholesterol or shea buter are weighed see.
Formulation and evaluation of niosomes encapsulated with kt2 and rt2. Moreover, carrageenan induced paw edema inhibition i. Formulation and evaluation of niosomes of benzyl penicillin. A diverse range of materials have been used to form niosomes such as sucrose ester surfactants and polyoxyethylene alkyl ether surfactants, alkyl ester, alkyl amides, fatty acids and amino acid compound. Formulation and evaluation of fluconazole proniosomal gel. Formulation and evaluation of sustained released niosomes containing pregabalin p. Formulation evaluation and optimization of niosomal gel of.
Drug delivery through niosomes is one of the approaches to achieve localised drug action in regard to their size and low penetrability through epithelium and connective tissue, which keeps the drug localised at the site of administration. Transdermal drug delivery utilizing niosomal technology is widely used in cosmetics. Niosomes formulations were characterized with respect to shape, particle size distribution, entrapment efficiency, in vitro release studies, zeta potential, polydispersity index, and stability profile. Formulation and evaluation of zidovudine loaded niosomes. Lower stability, tion of niosomes as alternative promising drug carriers to liposomal vesicles for industrial production uchegbu et al. Formulation and evaluation of metformin hydrochlorideloaded niosomes as controlled release drug delivery system azza a. Formulation, characterization and in vitro evaluation of.
These are very small, and microscopic in size that lies in the nanometric scale. Formulation and evaluation of a topical niosomal gel. Niosomes, proniosomes, nonionic surfactant, cholesterol. Formulation and evaluation of niosomes indian journal of.
Formulation and evaluation of ketoconazole niosomes abstract. Niosomes and liposomes are equiactive in drug delivery potential and both increase drug efficacy as compared with that of free drug. Niosomes of hydroxyl propyl methyl cellulose in this type, a base containing 10% glycerin of hydroxy propyl methyl cellulose was. Span 20based niosome was prepared by lipid film hydration technique and loaded with newcastle disease vaccine. Niosomes or nonionic surfactant vesicles are microscopic lamellar. Pdf formulation and evaluation of niosomes researchgate. Formulation and evaluation of metformin hydrochloride. Pdf formulation and evaluation of niosomes semantic. Candesertan niosomesformulation and evaluation using span. Ciprofloxacin encapsulated niosomes were formulated by thin film hydration. Formulation and evaluation international journal of. Niosomes are now widely studied as an alternative to liposomes. Formulation and evaluation of ocular niosomal in situ gels.
Arulkumaran kmch college of pharmacy, coimbatore, tamilnadu india abstract the main objective of the present study was to encapsulate pregabalin in niosomes for achieving prolonged release. Inclusion of cholesterol in niosomes increases its hydrodynamic diameter and entrapment efficiency 15. Pdf span 20based niosome was prepared by lipid film hydration technique and loaded with newcastle disease vaccine. Application of niosomes in cosmetics and therapeutics may offer several advantages. Niosomes are unilamellar or multilamellar vesicles. Formulation and invitro evaluation of niosomes of aceclofenac.
The niosomal formulations were characterised for vesicle size distribution, sem and zeta potential. Formulation and evaluation of niosomes encapsulated with. In vitro and in vivo evaluation of niosomal formulation for. Niosomes are formed on the admixture of nonionic surfactant of the alkyl or dialkylpolyglycerol ether class and cholesterol with subsequent hydration in. Pdf formulation and evaluation of methotrexate niosomes.
In general, the action of cholesterol is two folds. Stability of dry proniosomes is expected to be more stable than a premanufactured niosomal formulation. Design, formulation, and evaluation of piroxicam niosomal gel. Formulation and evaluation of methotrexate niosomes. Formulation and in vivo evaluation of niosomes containing. Niosomes are nonionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. Antiglaucoma activity of the prepared gel formulations showed more significant and sustained effect in reducing intra ocular pressure than marketed and niosomal drops. The objective of the present study was incorporation pir niosomes in different gel bases to develop pir gel for tansdermal delivery. Formulation and evaluation pranshu tangri1, shaffi khurana1 ditfaculty of pharmacy mussoorie diversion road, bhagwantpura, dehradun, uttarakhand248001 abstract niosomes are nonionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. Niosomes are formed on the admixture of nonionic surfactant of the alkyl or dialkylpolyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Pdf formulation and evaluation of niosomes semantic scholar. Abstract methotrexate was encapsulated in niosomes prepared using tweens and spans.
The niosomal formulation was transformed into gel when it instilled into the eye. Pdf formulation and evaluation of miconazole niosomes. Formulation evaluation and optimization of niosomal gel of piroxicam 2 advantages of niosomes. Abstract the aim of the study is to develop a proniosomal gel for nebivolol used for the treatment of hypertension that is. The prepared niosomes were evaluated for entrapment efficiency, size analysis and in vitro release studies. Proniosomes minimize of niosomes physical instability such as aggregation, fusion and leaking. Niosomes may be unilamellar or multilamellar depending on the method used to prepare them. Hasan1,2, hafez madkor3,4, and sherief wageh5,6 1department of pharmaceutical sciences, college of clinical pharmacy, king faisal university, alahsa, hufof, saudi arabia, 2department of. Design, formulation, and evaluation of piroxicam niosomal gel ahmed m. Devanna 2 department of pharmaceutics, pulla reddy institute of pharmacy 1, medak, andhra pradesh, india department of chemistry, jntua 2, ananthapur, andhra pradesh, india abstract.
Where dqdt is the permeation rate at steady state slope of the cumulative flux curve. Candesertan niosomesformulation and evaluation using span 60 as nonionic surafactant p. Niosomes containing span 60 displayed higher percentage of drug release after 24 h as. Formulation and evaluation of topical drug delivery system containing clobetasol propionate niosomes dissertation submitted to the tamilnadu dr. This research article focuses on the concept of niosomes, advantages and disadvantages, composition, method of preparation, factors that influence the niosomal formulation and characterization, application of niosomes. Formulation and evaluation of ketoconazole niosomal gel. A diverse range of materials have been used to form niosomes such as sucrose ester surfactants and polyoxyethylene alkyl ether surfactants, alkyl ester, alkyl amides, fatty acids and. Pdf formulation and evaluation of econazole niosomes. Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery author links open overlay panel prabagar balakrishnan a srinivasan shanmugam a won seok lee a won mo lee a jong oh kim a dong hoon oh a daeduk kim b jung sun kim c bong kyu yoo a hangon choi a jong soo woo a chul soon yong a. Proniosomederived niosomes are superior to conventional niosomes in convenience of storage, transport, distribution and dosing. In vitro and in vivo evaluation of niosomal formulation. The niosomal formulation containing drugloaded niosomes. The formulations were also tested for in vitro cupplate method and in vivo antifungal activity in rabbits and compared with free ketoconazole.
Niosomes are vesicles composed of nonionic surfaceactive agent bilayers, which serve as novel drug delivery systems. A microscopic evaluation of niosomes is the surface area of the diffusion membrane 1. Nystatin is bacterial originated polyene antifungal agent. Formulation and evaluation of niosomes article pdf available in indian journal of pharmaceutical sciences 733.
Pir niosomes were prepared by lipid evaporation method and all. The results of the present study indicate that niosomes have the potential to reduce the therapeutic dose of ketoconazole by improving its performance. Research article formulation and evaluation of metformin. Tem analyses showed that niosomal formulation was spherical in shape. Niosomes are microscopic in size and their size lies in the nanometric scale. Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy srishti agarwal,a m. Ramesh department of pharmaceutics, creative educational societys college of. Niosomes have attracted a great deal of attention in controlled drug delivery systems because of many advantages, such as biodegradability, nonimmunogenicity nature, bioavailability and effective in the modulation of drug release properties. This study was to investigate the feasibility of using niosome as a transdermal drug delivery system for miconazole. Formulation and invivo evaluation of niosome encapsulated daunorubicin. Evaluations of quality by design qbd elements impact for. Ankush gupta, 1, sima singh, 1, niranjan g kotla, 1 and thomas j webster 2, 3.
Topically applied niosomes can increase residence time of drug in the stratum corneum and epidermis, while reducing the systemic absorption of the drug. Formulation and evaluation of zidovudine loaded niosomes ranga priya m, natarajan r, and rajendran nn. Formulation and evaluation of methotrexate niosomes article pdf available in drug development and industrial pharmacy 1911. The size distribution, entrapment efficiency, pharmacokinetics and effect on tumour remission of mice transplanted with s180 sarcoma were evaluated. Formulation and in vitro assessment of minoxidil niosomes. Introduction methods of preparation evaluation of niosomes applications of niosomes 2 3. Localised drug action enhances efficacy of potency of the drug and, at the same time, reduces its systemic toxic effects, eg, antimonials encapsulated within niosomes are taken up by mononuclear cells, resulting in localisation of drug, increase in potency, and hence decrease in dose as well as toxicity. Also, niosomes by their nonionic nature and admirable biodegradability have shown excellent. Medical university, chennai in partial fulfillment of the requirement for the award of degree of master of pharmacy in pharmaceutics march 2008 department of pharmaceutics madurai medical college. Antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Formulation and evaluation of moxifloxacin hydrochloride. Onuigbo, booktitleindian journal of pharmaceutical sciences, year2011.
The optimized niosomal formulation was incorporated into carbopol gel and extensively characterized for percentage drug entrapment pde and in. Kumar and others published formulation and evaluation of econazole niosomes find, read and cite all the. Further, the niosomes were evaluated for nasal absorption using an ex vivo animal model. Niosomes niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle composed of a bilayer of nonionic surface active agents. Chima okore and anthony amaechi attama and kenneth c. Formulation, characterization and in vitro evaluation of tactically engineered proniosomes for successful oral delivery of ramipril meenakshi k. Sahoo 1, ashwani singh rawat 1, divya duggal 1, mayank kandwal 1and nidhi sandal 2 1department of pharmaceutics, delhi institute of pharmaceutical sciences and research.